5YQZ | pdb_00005yqz

Structure of the glucagon receptor in complex with a glucagon analogue

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth R]	SCOP2 Family	Class B (secretin) G protein-coupled receptor-like	8091137	4007725	SCOP2 (2022-06-29)
A [auth R]	SCOP2 Family	Hormone receptor domain	8091139	4003045	SCOP2 (2022-06-29)
A [auth R]	SCOP2 Superfamily	G protein-coupled receptor-like	8091138	3000473	SCOP2 (2022-06-29)
A [auth R]	SCOP2 Superfamily	FnI-like domain	8091140	3000979	SCOP2 (2022-06-29)
A [auth R]	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth R]	7tm_2	e5yqzR3	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_2	ECOD (1.6)
A [auth R]	Phage_lysozyme_2	e5yqzR2	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
A [auth R]	HRM	e5yqzR1	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: HRM	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth R]	4.10.1240.10	Few Secondary Structures	Irregular	Hormone receptor fold	GPCR, family 2, extracellular hormone receptor domain	CATH (utative)
A [auth R]	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth R]	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A [auth R]	PF02793	Hormone receptor domain (HRM)	Hormone receptor domain	-	Family
A [auth R]	PF00002	7 transmembrane receptor (Secretin family) (7tm_2)	7 transmembrane receptor (Secretin family)	This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognise ...	This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognised. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97 (Swiss:P48960); calcium-independent receptors for latrotoxin (such as Swiss:O94910), and brain-specific angiogenesis inhibitors (such as Swiss:O14514) amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins (e.g. Swiss:P83119). Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling [1].	Domain
B [auth P]	PF00123	Peptide hormone (Hormone_2)	Peptide hormone	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth R]	Glucagon receptor,Endolysin,Glucagon receptor	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity glucagon receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity signaling receptor activity transmembrane signaling receptor activity amide binding hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity glucagon receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity signaling receptor activity transmembrane signaling receptor activity amide binding binding peptide hormone binding hormone binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	defense response to bacterium biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to bacterium response to stress response to external stimulus response to external biotic stimulus response to biotic stimulus carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process defense response to bacterium biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to bacterium response to stress response to external stimulus response to external biotic stimulus response to biotic stimulus carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process aminoglycan metabolic process peptidoglycan metabolic process metabolic process cellular process macromolecule metabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis exit from host cell viral process cytolysis in another organism viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation regulation of biosynthetic process regulation of biological process regulation of cellular process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular response to stimulus cellular response to nitrogen compound response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound response to glucagon cellular response to oxygen-containing compound cellular response to glucagon stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to hormone stimulus carbohydrate metabolic process energy derivation by oxidation of organic compounds glycogen metabolic process primary metabolic process regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process glucan metabolic process polysaccharide metabolic process energy reserve metabolic process regulation of glycogen metabolic process regulation of carbohydrate metabolic process signaling cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to nutrient levels response to nutrient levels cellular response to stress response to starvation cellular response to starvation cell surface receptor signaling pathway response to nutrient chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis	host cellular component host intracellular part cellular anatomical structure host cell cytoplasm host cell part host intracellular region membrane cell periphery plasma membrane
B [auth P]	Glucagon analogue	protein binding binding signaling receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity G protein-coupled receptor binding glucagon receptor binding hormone activity identical protein binding	monosaccharide metabolic process regulation of cellular process positive regulation of biological process gluconeogenesis regulation of primary metabolic process positive regulation of metabolic process regulation of small molecule metabolic process positive regulation of biosynthetic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of cellular process positive regulation of gluconeogenesis regulation of biosynthetic process monosaccharide metabolic process regulation of cellular process positive regulation of biological process gluconeogenesis regulation of primary metabolic process positive regulation of metabolic process regulation of small molecule metabolic process positive regulation of biosynthetic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of cellular process positive regulation of gluconeogenesis regulation of biosynthetic process carbohydrate metabolic process regulation of biological process small molecule biosynthetic process carbohydrate biosynthetic process biological regulation hexose metabolic process primary metabolic process monosaccharide biosynthetic process hexose biosynthetic process positive regulation of glucose metabolic process biosynthetic process regulation of gluconeogenesis metabolic process cellular process positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process regulation of metabolic process glucose metabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular response to nitrogen compound response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound response to glucagon cellular response to oxygen-containing compound cellular response to glucagon stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to hormone stimulus response to activity adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway protein kinase A signaling negative regulation of execution phase of apoptosis regulation of execution phase of apoptosis execution phase of apoptosis behavior multicellular organismal process feeding behavior adenylate cyclase-activating G protein-coupled receptor signaling pathway protein localization regulation of localization establishment of protein localization nitrogen compound transport localization cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport hormone secretion protein localization to extracellular region peptide secretion regulation of secretion by cell secretion by cell amide transport signal release regulation of transport secretion regulation of peptide transport regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport insulin secretion positive regulation of establishment of protein localization carbohydrate homeostasis establishment of localization in cell positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion positive regulation of peptide hormone secretion intracellular glucose homeostasis cellular response to carbohydrate stimulus chemical homeostasis response to glucose glucose homeostasis positive regulation of protein localization insulin secretion involved in cellular response to glucose stimulus homeostatic process positive regulation of secretion by cell positive regulation of protein transport positive regulation of hormone secretion response to monosaccharide response to carbohydrate positive regulation of secretion cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of peptide secretion cellular response to glucose stimulus positive regulation of protein secretion response to hexose cellular homeostasis positive regulation of transport regulation of insulin secretion involved in cellular response to glucose stimulus regulation of calcium ion import regulation of calcium ion transport positive regulation of calcium ion transport positive regulation of calcium ion import regulation of monoatomic ion transport calcium ion transport metal ion transport positive regulation of monoatomic ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport	cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle vesicle extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth R]	IPR052619	Bacteriophage lysozyme-like	Family
A [auth R]	IPR001165	T4-type lysozyme	Family
A [auth R]	IPR034690	Endolysin T4 type	Family
A [auth R]	IPR002196	Glycoside hydrolase, family 24	Family
A [auth R]	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A [auth R]	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
A [auth R]	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
A [auth R]	IPR050332	G-protein coupled receptor 2	Family
A [auth R]	IPR003290	GPCR, family 2, glucagon-like peptide-1/glucagon receptor	Family
A [auth R]	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
A [auth R]	IPR000832	GPCR, family 2, secretin-like	Family
A [auth R]	IPR017981	GPCR, family 2-like, 7TM	Domain
A [auth R]	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain
A [auth R]	IPR003291	GPCR, family 2, glucagon receptor	Family
B [auth P]	IPR000532	Glucagon/GIP/secretin/VIP	Domain
B [auth P]	IPR015550	Glucagon	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth R]	Pharos: P47871	type 2 diabetes mellitus acquired metabolic disease diabetes mellitus hypoglycemia Severe hypoglycaemia in patients with diabetes ACTH-independent macronodular adrenal hyperplasia 1 Cushing syndrome due to macronodular adrenal hyperplasia maturity-onset diabetes of the young
B [auth P]	Pharos: P01275	obesity disorder hyperglycemia hyperinsulinism type 2 diabetes mellitus malignant colon neoplasm hypertensive disorder Aberrant Crypt Foci colitis congestive heart failure vascular disease heart disease poisoning stomach disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia heart failure obesity disorder hyperglycemia hyperinsulinism type 2 diabetes mellitus malignant colon neoplasm hypertensive disorder Aberrant Crypt Foci colitis congestive heart failure vascular disease heart disease poisoning stomach disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia heart failure prediabetes syndrome hyperlipidemia kidney disease coronary artery disease pancreatic insulinoma pancreatitis hypotensive disorder Crohn disease maturity-onset diabetes of the young non-alcoholic fatty liver disease familial hyperlipidemia pancreatic intraductal papillary-mucinous carcinoma short bowel syndrome hyperinsulinemic hypoglycemia benign colon neoplasm hypoglycemia colonic neoplasm inherited lipid metabolism disorder constipation disorder metabolic acidosis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth R], B [auth P]	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	GPCR Secretin (B) family

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth R], B [auth P]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth R], B [auth P]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class B1	glucagon receptor (GCGR), full length in complex with glucagon analog NNC1702

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

	
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